Severe primary IGF-1 deficiency
Severe primary IGF-1 (insulin-like growth factor 1, a protein that mediates the effects of growth hormone) deficiency causes delayed growth in children and adolescents, as well as a range of anatomical, morphological and physiological disorders. Learn more about the condition, its diagnosis and the different treatment options available.
In practice, severe primary IGF-1 deficiency is the diagnosis for children with:
- small stature (< -3SD*),
- low IGF-1 serum level (age adjusted),
- normal or high GH serum level.
*SD: standard deviation used to measure the dispersion of measures around the mean.