Severe primary IGF-1 deficiency

Severe primary IGF-1 (insulin-like growth factor 1, a protein that mediates the effects of growth hormone) deficiency causes delayed growth in children and adolescents, as well as a range of anatomical, morphological and physiological disorders. Learn more about the condition, its diagnosis and the different treatment options available.

In practice, severe primary IGF-1 deficiency is the diagnosis for children with:

  • small stature (< -3SD*),
  • low IGF-1 serum level (age adjusted),
  • normal or high GH serum level.

*SD: standard deviation used to measure the dispersion of measures around the mean.

Last update 13/04/2017